i.e. Edit c:\Windows\System32\Drivers\etc\hosts
Add
127.0.0.1 localtest44.localtestdomain.com
127.0.0.1 localtest44-1.localtestdomain.com
127.0.0.1 localtest44-2.localtestdomain.com
Then in Visual Studio edit the Nop.Web Debug Properties and add an IIS Configuration using the domain localtest44.localtestdomain.com
After the website is running create new stores and map them with the other domains above
To switch stores enter another domain one of the above domains in the browser